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Montag, 8. November 2010
Medizin Bisphenol A geht durch die HautToulouse/Boston – Das Thermopapier, mit dem viele Kassenbelege gedruckt werden, ist mit der Chemikalie Bisphenol A (BPA) belastet. Es wird über die Haut aufgenommen, was die hohe Exposition bei Supermarktkassiererinnen erklärt.
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mehr:
http://www.aerzteblatt.de/nachrichten/43404/Bisphenol_A_geht_durch_die_Haut.htmAbstract der Studien:
http://www.ncbi.nlm.nih.gov/pubmed/21030062Chemosphere. 2010 Oct 26. [Epub ahead of print]
Viable skin efficiently absorbs and metabolizes bisphenol A.Zalko D, Jacques C, Duplan H, Bruel S, Perdu E.
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INRA, UMR1089 Xénobiotiques, 180 Chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France.
AbstractSkin contact has been hypothesized to contribute to human exposure to bisphenol A (BPA). We examined the diffusion and metabolism of BPA using viable skin models: human skin explants and short-term cultures of pig ear skin, an alternative model for the study of the fate of xenobiotics following contact exposure. (14)C-BPA [50-800nmol] was applied on the surface of skin models. Radioactivity distribution was measured in all skin compartments and in the diffusion cells of static cells diffusion systems. BPA and metabolites were further quantified by radio-HPLC. BPA was efficiently absorbed in short-term cultures, with no major difference between the models used in the study [viable pig ear skin: 65%; viable human explants: 46%; non-viable (previously frozen) pig skin: 58%]. BPA was extensively metabolized in viable systems only. Major BPA metabolites produced by the skin were BPA mono-glucuronide and BPA mono-sulfate, accounting together for 73% and 27% of the dose, in pig and human, respectively. In conclusion, experiments with viable skin models unequivocally demonstrate that BPA is readily absorbed and metabolized by the skin. The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs.
Copyright © 2010. Published by Elsevier Ltd.
PMID: 21030062
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http://ehp03.niehs.nih.gov/article/info%3Adoi%2F10.1289%2Fehp.1002366[*QUOTE*]
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Research Article
Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy * Article
Formal Correction: This article has been formally corrected to address the following errors.
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Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, John T. Bernert, Xiaoyun Ye, Manori J. Silva, Dana Boyd Barr, Sheela Sathyanarayana, Bruce P. Lanphear
Abstract Top
Background: Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy.
Objective: To estimate the variability and predictors of serial urinary BPA concentrations taken during pregnancy.
Methods: We measured BPA concentrations during pregnancy and at birth in three spot urine samples from 389 women. We calculated the intraclass correlation coefficient (ICC) to assess BPA variability and estimated associations between log10-transformed urinary BPA concentrations and demographic, occupational, dietary, and environmental factors using mixed models.
Results: Geometric mean (GM) creatinine-standardized concentrations (μg/g) were 1.7 (16 weeks), 2.0 (26 weeks), and 2.0 (birth). Creatinine-standardized BPA concentrations exhibited low reproducibility (ICC: 0.11). By occupation, cashiers had the highest BPA concentrations (GM: 2.8 μg/g). Consuming canned vegetables at least once a day was associated with higher BPA concentrations (GM: 2.3 μg/g) compared to those consuming no canned vegetables (GM: 1.6 μg/g). BPA concentrations did not vary by consumption of fresh fruits and vegetables, canned fruit, or store-bough fresh and frozen fish. Urinary high molecular weight phthalate and serum tobacco smoke metabolite concentrations were positively associated with BPA concentrations.
Conclusions: These results suggest that numerous sources of BPA exposure during pregnancy exist. Etiological studies may need to measure urinary BPA concentrations more than once during pregnancy and adjust for phthalates and tobacco smoke exposures.
Citation:
Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, et al. 2010. Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy. Environ Health Perspect :-. doi:10.1289/ehp.1002366---------------------------------------------------------------------
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