Genomic Homeopathy proposal
Rev Assoc Med Bras (1992). 2023 Jan 9;69(1):13-17
"Genomic Homeopathy" proposal: use of auto-isotherapic of DNA as a modulator of gene expression in chronic diseases
Marcus Zulian Teixeira
Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Psiquiatria - São Paulo (SP), Brazil.
(no abstract)
Free full text:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937616/Rather than quote extensively from this article, I will just summarize some of its points and give some brief quotes.
Vital functions of the body are controlled by the genome (the exome, or protein-coding portion, plus the epigenome, chemical changes modifying the genome).“...the primary cause of diseases is in disease-coding genes. In turn, these disease-promoting gene expressions are modulated by the epigenome.”
[Note: the paper is incorrect. “The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of junk DNA with no evident function.” - Wikipedia. The epigenome is not considered part of the genome but rather a set of modifications of it. In a later section the paper says “While the exome makes up 2% of the genome, the epigenome is formed by the remaining 98% of it...” However, the remaining 98% is the noncoding regions, not the epigenome.]
“...we infer the hypothesis that the genome...is the representation or biological substrate of the vital force or principle...while disease-promoting epigenetic alterations are the representation or biological substrate of chronic miasms. Similarly, we infer that telomeres (terminal portion of chromosomes) are markers of the state of vital force or principle as they are considered biomarkers of cellular vitality, aging, and the health disease process.”
“we have suggested using auto-isotherapic (auto-sarcode) of DNA (medicine prepared with the patient's own DNA, according to homeopathic pharmacotechnics) as a homeopathic treatment that stimulates the body's vital (homeostatic) reaction and the gene expression modulation in chronic diseases. In contrast, we have suggested using telomere length as a marker of the effectiveness of homeopathic treatment.”
This hypothesis is proposed as the basis for a new research program.
Homeopathic medications restore the balance of the vital force.
According to the biomedical model, vital functions are controlled by the biochemical information in DNA, and “...physiological imbalances and most chronic diseases are manifested as a result of changes in the patterns of this gene expression.”
“...we infer the hypothesis that the genome (exome plus epigenome) is the representation or the biological substrate of the vital force or principle.”
“In the homeopathic miasmatic conception, the dynamic action of chronic miasms is the fundamental cause for manifesting chronic diseases, as well as the main obstacle to their natural resolution.”
In the biomedical model, epigenetic alterations can be made to the DNA. These changes can be passed on to offspring. They are reversible. They can be expressed in the genomes of individuals as a result of lifestyle or environmental factors.
So miasms are like epigenetic modifications leading to chronic disease.
Experimental studies show that homeopathic medicines act by regulating gene expression.
“...the genome (exome plus epigenome) would be the simillimum of the vital force and the epigenetic alterations that promote chronic diseases would be the simillimum of miasms.”
“Grounded in these hypotheses and using the reactional treatment method called ‘isopathy’ (‘a method of curing a given disease by the same contagious principle that produces it’) described by Hahnemann...we are suggesting administering the homeopathic medicine prepared with the patient's own DNA (auto-isotherapic of DNA) with the aim of awakening a dynamic, complex, and self-organizing therapeutic reaction of the vital principle or genome, thereby respectively promoting the vital balance or modulating gene expression in chronic diseases.”
“Following the ‘Minimum Requirements for the Preparation of Biotherapics and Isotherapics,’ complying with the biosafety norms of the Brazilian health surveillance, ‘auto-isotherapics can only be stored in alcohol at 70% (v/v) and dispensed from 12cH,’ meaning in concentrations less than 10^23 mol^-1 according to homeopathic pharmacotechnics (Table 1), which are below the Avogadro limit (6.02×10^23 mol^-1).” [Note: the units used here don’t make sense. “10^23 mol^-1" is not a unit of concentration. What the author means is that a 12cH product has been diluted 10^24 times, so that if you started with a 1 M concentration (which would be much higher than you would get for DNA) and diluted it that much, there would be less than one molecule per liter.]
A table describes the proposed method of preparing the auto-isotherapic of DNA.
There are some similarities of this method to vaccines. However, because the dose is so small it will be “safe and free from significant adverse effects.”
“If the auto-isotherapic of DNA is able to stimulate a constitutional modulation of vital force or gene expression, it will exert systemic action in preventing and treating organic disorders and chronic diseases in general.
“It is important to reiterate that this is a theoretical hypothesis and without scientific evidence so far, and its use in humans can only be disseminated after studies attest to its safety and efficacy. Therefore, the preliminary disclosure of this innovative proposal is intended to unite researchers around it, encouraging research that confirms or refutes its validity.”
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Comment: as noted, this is just a proposal for a new type of homeopathic medicine. We might expect that someone will start producing such remedies in the future.
