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Aktuell im WWW => Hinweise auf Neues/Interessantes/Wichtiges im WWW => Topic started by: ama on November 24, 2007, 08:08:16 PM
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23.11.2007
Wo die Migräne herkommt
Somatosensorischer Kortex bei Betroffenen um durchschnittlich 21 Prozent dicker als bei anderen Menschen
New York - Migräne-Patienten weisen in einem bestimmten Hirnareal typische
Veränderungen auf. Eine US-Studie zeigt, dass bei Menschen, die unter den
regelmäßigen Kopfschmerzattacken leiden, der sogenannte somatosensorische
Kortex um durchschnittlich 21 Prozent dicker ist als bei anderen Menschen.
Diese Hirnregion ist an der Verarbeitung von körperlichen Reizen wie etwa
Schmerz beteiligt.
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mehr:
http://derstandard.at/Text/?id=3124357
Die Nachrichten direkt von der Quelle:
http://www.neurology.org/cgi/content/abstract/69/21/1990
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NEUROLOGY 2007;69:1990-1995
© 2007 American Academy of Neurology
Thickening in the somatosensory cortex of patients with migraine
Alexandre F.M. DaSilva, DDS, DMSc,
Cristina Granziera, MD, PhD, Josh Snyder and
Nouchine Hadjikhani, MD
From Martinos Center for Biomedical Imaging, Massachusetts General
Hospital, Harvard Medical School, Charlestown, MA (A.F.M.D., C.G.,
J.S., N.H.); and Division of Health Sciences and Technology,
Massachusetts Institute of Technology, Cambridge, MA (N.H.). Dr.
DaSilva is currently with the P.A.I.N. Group, Brain Imaging Center,
McLean Hospital, Harvard Medical School, Belmont, MA.
Address correspondence and reprint requests to Dr. Nouchine
Hadjikhani, Martinos Center for Biomedical Imaging, Massachusetts
General Hospital, Harvard Medical School, Bldg. 36, First St., Room
417, Charlestown, MA 02129 nouchine{at}nmr.mgh.harvard.edu
Objective:
To examine morphologic changes in the
somatosensory cortex (SSC) of patients with migraine.
Methods:
Cortical thickness of the SSC of patients with migraine was
measured in vivo and compared with age- and sex-matched healthy
subjects. The cohort was composed of 24 patients with migraine,
subdivided into 12 patients who had migraine with aura, 12 patients
who had migraine without aura, and 12 controls. Group and individual
analyses were performed in the SSC and shown as average maps of
significant changes in cortical thickness.
Results:
Migraineurs had on average thicker SSCs than the control
group. The most significant thickness changes were noticed in the
caudal SSC, where the trigeminal area, including head and face, is
somatotopically represented.
Conclusions:
Our findings indicate the presence of interictal structural
changes in the somatosensory cortex (SSC) of migraineurs. The SSC
plays a crucial role in the noxious and nonnoxious somatosensory
processing. Thickening in the SSC is in line with diffusional
abnormalities observed in the subcortical trigeminal somatosensory
pathway of the same migraine cohort in a previous study. Repetitive
migraine attacks may lead to, or be the result of, neuroplastic changes in
cortical and subcortical structures of the trigeminal somatosensory
system.
Abbreviations:
CS = central sulcus;
DTI = diffusion tensor imaging;
FA = fractional anisotropy;
GPoC = gyrus postcentralis;
GprC = gyrus precentralis;
HC = healthy control;
IRB = institutional review board;
MP-RAGE = magnetization-prepared rapid acquisitions with gradient echoes;
MWA = migraine with aura;
MWoA = migraine without aura;
ROI = region of interest;
SMC = sensorimotor cortex;
SPoC = sulcus postcentralis;
SSC = somatosensory cortex.
Supported by NIH grant 5P01 NS 35611-09 (N.H., A.F.M.D., J.S.), the Swiss Heart Foundation (C.G.), and the Dean's award
of Harvard School of Dental Medicine (A.F.M.D.).
Disclosure: The authors report no conflicts of interest.
Received February 12, 2007. Accepted in final form June 3, 2007.
Copyright © 2007 by AAN Enterprises, Inc.
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der Volltext:
http://www.neurology.org/cgi/reprint/69/21/1990
.